Ozone Therapy NYC - Dr. John Salerno

Man in chair receiving IV Ozone Therapy NYC, looking at a tablet indoors.

IV Ozone Therapy at Salerno Wellness in Manhattan, NY and Connecticut

Ozone therapy works by activating your body’s natural healing mechanisms. It increases the amount of oxygen your body tissues receive while boosting immune health. I incorporate ozone therapy into a comprehensive regimen at Salerno Wellness to reduce inflammation, treat Lyme Disease, Chronic Fatigue Syndrome, Fibromyalgia, Mold Toxicity, viral infections, wounds, and cardiovascular disease, which have all proven to improve my patients' health. 

-Dr. John Salerno

What is Ozone Therapy?


Ozone therapy is a powerful, medical-grade treatment that uses ozone, a colorless gas composed of three oxygen atoms, to stimulate the body’s healing mechanisms. This therapy has been used safely and effectively worldwide for over a century to disinfect and treat diseases by improving oxygen utilization in the body. Unlike the oxygen we breathe, which contains two atoms, ozone contains three atoms, making it supercharged and highly active in biological systems. It is administered in various forms depending on the patient's needs, including intravenous applications or direct tissue injections.


The primary goal of this therapy is to boost the immune system and deactivate bacteria, viruses, fungi, yeast, and protozoa. It is a natural way to detoxify the body and reduce chronic inflammation, which is the root of many modern diseases. By increasing the body's oxygen levels, we can help cells function more efficiently and repair damaged tissues. Ultimately, it serves as a potent tool in regenerative medicine to revitalize energy and health.

How Does Ozone Therapy Work?


When ozone is introduced into the body, it reacts immediately with biological fluids, forming peroxides and other beneficial compounds that signal the immune system to wake up. This reaction increases red blood cell production and improves the flexibility of their membranes, allowing them to travel through tiny capillaries more easily. As a result, oxygen delivery to tissues and organs is significantly enhanced, a crucial factor for cellular repair and energy production.


Ozone therapy also stimulates the production of powerful antioxidant enzymes that protect healthy cells while simultaneously attacking pathogens. It works by disrupting the integrity of bacterial and viral cell envelopes, effectively neutralizing infections that may be resistant to traditional antibiotics. Furthermore, ozone helps modulate the immune system, calming it when it is overactive, as in autoimmune diseases, or boosting it when it is suppressed. By optimizing oxygen utilization and reducing oxidative stress, the body can shift from a state of illness to a state of regeneration.

Conditions Ozone Therapy Treats


  • Lyme Disease Lyme disease is a complex bacterial infection transmitted by ticks that can cause severe fatigue, joint pain, and neurological issues. Ozone therapy helps by directly targeting the spirochete bacteria responsible for the disease and reducing the systemic inflammation they cause.


  • Autoimmune Diseases Conditions like rheumatoid arthritis and lupus occur when the immune system mistakenly attacks the body's own tissues. Ozone therapy acts as an immune modulator, helping to balance the immune response and prevent further tissue damage.


  • Chronic Fatigue Syndrome This debilitating disorder is characterized by extreme tiredness that doesn't improve with rest and may worsen with physical or mental activity. By improving cellular oxygenation and mitochondrial function, ozone therapy can help restore energy levels and mental clarity.


  • Fibromyalgia Patients with fibromyalgia suffer from widespread musculoskeletal pain accompanied by fatigue, sleep, and mood issues. Ozone treatments help reduce pain signals and improve circulation, offering relief from the chronic aches associated with this condition.


  • Mold Toxicity Exposure to toxic mold can lead to respiratory issues, brain fog, and a compromised immune system. Ozone is a potent antifungal agent that helps detoxify the body and eliminate fungal pathogens from the system.


  • Viral Infections (Herpes, Epstein-Barr, Shingles) - Chronic viral infections can lie dormant in the body and flare up when the immune system is weak. The antiviral properties of ozone help to lower the viral load and prevent frequent outbreaks by disrupting viral replication.


  • Wound Healing and Diabetic Ulcers - Non-healing wounds, particularly in diabetic patients, pose a serious risk of infection and amputation. Ozone therapy accelerates tissue regeneration and disinfects the wound site, significantly speeding healing.


  • Cardiovascular Disease - Poor circulation and arterial plaque buildup contribute to heart disease and stroke risk. Ozone therapy improves blood rheology, or flow, and reduces oxidative stress on the blood vessels, supporting better heart health.

Common Symptoms of People Who May Be Treated with Ozone Therapy


Many patients who benefit from this therapy report a persistent feeling of exhaustion that does not resolve even after a full night of sleep. You might experience chronic pain in your joints or muscles that limits your mobility and affects your daily activities. Frequent infections or a sense that you are always "catching something" can indicate a weakened immune system that needs support. Brain fog, difficulty concentrating, and memory lapses are also common complaints among those struggling with underlying systemic issues.


Digestive problems such as bloating, gas, or irregular bowel movements often accompany these other symptoms, signaling gut health imbalances. Some patients notice that their recovery time from workouts or minor injuries is much longer than it used to be. Unexplained skin rashes or slow-healing wounds can also be a sign that your body’s regenerative capabilities are compromised. If you feel like you are aging faster than you should or simply lack the vitality you once had, this treatment may be appropriate.


Common Causes of Patients Who Have Been Treated with Ozone Therapy


The root causes leading patients to seek this therapy are often multifaceted, involving environmental toxins that accumulate in the body over time. Chronic stress is a major contributor, as it depletes the body’s reserves and weakens the immune system's ability to fight off pathogens. Poor dietary choices, particularly the consumption of processed foods and high sugar intake, lead to systemic inflammation and gut dysbiosis. Exposure to heavy metals, pesticides, and household chemicals can overwhelm the liver and detoxification pathways.


Underlying chronic infections, such as Lyme disease or reactivation of dormant viruses, often go undiagnosed for years while wreaking havoc on health. A sedentary lifestyle combined with poor oxygenation prevents cells from generating the energy required for repair. Genetic predispositions can also play a role, making some individuals more susceptible to oxidative stress and immune dysfunction. Finally, the overuse of antibiotics and other medications can disrupt the body's natural microbiome, leaving it vulnerable to disease.

Man in bed blowing his nose with a tissue a candidate for IV Ozone Therapy

Candidates for IV Ozone Therapy


The Ideal candidate for this therapy is someone who is dealing with chronic health issues that have not responded well to conventional medical treatments. If you are looking for a natural, non-toxic way to boost your immune system and improve your overall vitality, you may be a great fit. Patients suffering from autoimmune disorders, chronic infections, or persistent fatigue often see the most dramatic improvements. It is also an excellent option for individuals who want to be proactive about their health and focus on longevity and disease prevention.

Those who are willing to make complementary lifestyle changes, such as improving their diet and reducing stress, tend to get the best results. However, this treatment is not suitable for everyone, including pregnant women or individuals with certain enzyme deficiencies like G6PD deficiency. During our consultation, I will review your full medical history to determine if this is the safest and most effective path for you. We look for patients who are committed to a partnership in their health journey and open to integrative approaches.

What Can Happen Ff These Symptoms Are Left Untreated


Ignoring chronic symptoms and failing to address the root cause of illness can lead to a progressive decline in your overall health and quality of life. Without intervention, chronic inflammation can cause permanent damage to tissues, joints, and organs, leading to more severe disease states. Autoimmune conditions may worsen over time, requiring increasingly heavy doses of immunosuppressive medications that come with their own dangerous side effects. Chronic infections like Lyme disease can spread to the nervous system and heart if not effectively neutralized.


Untreated fatigue and brain fog can eventually impact your career, relationships, and ability to enjoy daily activities. The body’s toxic burden will continue to accumulate, further suppressing the immune system and leaving you vulnerable to new infections and even cancer. Accelerated aging processes are typical when oxidative stress is unmanaged, leading to frailty and earlier loss of independence. By delaying treatment, the path to recovery becomes more protracted, more difficult, and often more expensive to manage.

Why Patients Choose Dr. John Salerno for IV Ozone Therapy in NYC and CT


Patients choose me because they want a doctor who sees them as a person, not just a chart of symptoms or lab values. My extensive experience enables me to customize ozone therapy protocols to your unique physiology and health goals. I prioritize safety and efficacy, using only state-of-the-art equipment and the highest-grade medical ozone. My practice is built on a foundation of trust and compassion, ensuring that you feel supported every step of the way.


I take the time to explain the science behind the treatment so you feel empowered and knowledgeable about your care. Unlike high-volume clinics, we provide a boutique medical experience where your comfort and well-being are the top priority. My holistic approach ensures we support your body with proper nutrition and supplementation, alongside therapy, for maximum benefit. Ultimately, patients come to me because they are ready for real results and a doctor who is genuinely invested in their recovery.


I believe that true healing requires looking at the whole person rather than isolating specific organs or symptoms. Complementary, functional, and integrative medicine allows me to combine the best of traditional diagnostic tools with holistic therapies that support the body's natural healing abilities. This approach is not about a quick fix but about creating a sustainable path to wellness that accounts for your lifestyle, environment, and genetic makeup. We focus on prevention and optimization, ensuring that your body has exactly what it needs to function at its highest potential. By integrating various therapeutic modalities, we can create a personalized treatment plan that is as unique as you are.

Possible Side Effects


Ozone therapy is generally considered very safe when administered by a trained and experienced professional like myself. However, as with any medical treatment, some patients may experience mild side effects as the body begins to heal and detoxify. You might notice a temporary increase in fatigue or flu-like symptoms immediately after a session, often called a Herxheimer reaction. This occurs when toxins released by dying pathogens are eliminated faster than the body can eliminate them. Some patients may experience slight irritation or bruising at the injection site if intravenous methods are used. Rarely, shortness of breath or lightheadedness can occur, but these symptoms typically resolve quickly on their own. It is important to stay well-hydrated before and after treatment to help flush out metabolic waste. We closely monitor our patients during administration to ensure their comfort and safety throughout the process. Most side effects are transient and are actually a sign that the therapy is working to clear out the infection.

Ozone Therapy Patient Case Studies


Mark’s Recovery from Chronic Lyme


Mark came to see me after battling Lyme disease for over five years, suffering from debilitating joint pain and brain fog that made it impossible for him to work. He had tried multiple rounds of strong antibiotics, but his symptoms always returned with a vengeance once the medication stopped. We started a protocol of intravenous ozone therapy twice a week to target the persistent bacteria and reduce his systemic inflammation. After just four weeks, Mark reported that his energy levels had doubled, and the fog lifting from his mind was profound. By the end of his treatment course, his joint pain had completely resolved, and he was able to return to his job full-time. He now comes in for maintenance sessions occasionally but lives a completely normal, active life. His success story highlights the power of ozone in treating complex, resistant infections.


Mary Beth’s Journey with Fibromyalgia


Mary Beth arrived at my office exhausted and frustrated, dealing with widespread pain from fibromyalgia that left her bedridden most days. She was skeptical because she felt she had tried every medication and therapy available with little to no relief. We implemented a comprehensive plan that included ozone therapy to improve oxygenation in her muscles and modulate her pain receptors. Mary Beth noticed a significant decrease in her pain levels after her third session, describing it as a "turning down of the volume" on her suffering. As her pain subsided, her sleep quality improved dramatically, which further accelerated her healing process. Within three months, Mary Beth was able to start exercising again, something she hadn't done in years. She credits ozone therapy with restoring her independence and joy. Her transformation is a testament to the regenerative capabilities of this treatment.

Contact Dr. John Salerno To See If Ozone Therapy is the Right Treatment for You in Manhattan, NY, and Connecticut

Contact Dr. John Salerno To See If Ozone Therapy is the Right Treatment for You in Manhattan, NY, and Connecticut


You do not have to accept chronic pain, fatigue, or illness as your permanent reality. I am here to help you uncover the root causes of your symptoms and provide the advanced, integrative care you need to heal. Ozone therapy offers a safe, effective way to revitalize your body and reclaim your health.


If you are ready to start your journey toward wellness, I invite you to reach out to my office today. We can schedule a comprehensive consultation to discuss your history and determine if this treatment is right for you. Please contact us to book your appointment and take the first step toward a vibrant future.


Please contact us today.