NAD+ Treatments NYC - Dr. John Salerno

Nicotinamide Adenine Dinucleotide Treatments by Salerno Wellness in Manhattan, NY and Connecticut

Introducing NAD+ treatments at Salerno Wellness, a revolutionary therapy that replenishes your body's energy at the cellular level and promotes a healthy aging process, and more!. Restore this essential coenzyme and enjoy enhanced vitality, mental clarity, and overall well-being. 

-Dr. John Salerno

What is Nicotinamide Adenine Dinucleotide (NAD+)

Nicotinamide adenine dinucleotide, or NAD⁺, is a vital coenzyme found in every single living cell within your body and is essential for life itself. It acts as a critical "spark plug" that facilitates the conversion of the nutrients you eat into the cellular energy, known as ATP, that powers your entire system. Beyond energy production, this molecule plays a crucial role in maintaining the integrity of your DNA by fueling the enzymes that repair genetic damage.

As we age, our natural levels of this essential coenzyme decline significantly, often by as much as 50% by middle age. This decline compromises your cells' ability to repair themselves and produce energy efficiently, leading to the common signs of aging we all recognize. NAD⁺ treatments involve replenishing these depleted levels directly, bypassing the digestive system to ensure maximum absorption and immediate availability for your cells. By restoring these levels, we can effectively jumpstart your cellular machinery, improve mitochondrial function, and activate longevity pathways, including sirtuins.

How do NAD+ Treatments Work?

NAD⁺ treatments work by delivering high doses of this essential coenzyme directly into your bloodstream through intravenous infusions or other direct methods. Once in your system, the molecule rapidly enters your cells and immediately supports mitochondrial function, which generates the energy your body needs to survive. It activates specific enzymes called PARPs that detect and repair damaged DNA strands caused by environmental toxins, stress, and normal metabolic processes. Simultaneously, it stimulates a class of proteins called sirtuins, which regulate critical biological processes, including the inflammatory response, metabolism, and stress resistance.

By fueling these cellular repair mechanisms, the treatment helps reverse mitochondrial dysfunction and improve communication between the nucleus and mitochondria. This process essentially "cleans up" cellular debris and restores your tissues to a more youthful, efficient state of operation. The result is a systemic improvement in energy production, cognitive clarity, and physical resilience.

Conditions Nat+ Treatments Are Effective For

• Chronic Fatigue Syndrome - Patients with chronic fatigue often exhibit severe mitochondrial dysfunction, in which their cells cannot produce enough energy to meet daily demands. NAD⁺ therapy helps reboot these cellular powerhouses, providing a sustainable energy source that helps alleviate the crushing exhaustion associated with this condition.

• Neurodegenerative Diseases (Alzheimer's and Parkinson's) - These conditions are characterized by progressive loss of neuronal structure or function, often associated with mitochondrial dysfunction and oxidative stress. Replenishing NAD⁺ supports neuronal health and DNA repair in the brain, potentially slowing progression and protecting cognitive function against further degeneration.

• Anxiety and Depression - Mental health struggles are frequently connected to chemical imbalances and inflammation in the brain that disrupt neurotransmitter function. By reducing neuroinflammation and supporting optimal brain energy metabolism, this treatment can help stabilize mood and improve emotional resilience.

• Metabolic Disorders - Conditions like obesity and diabetes often involve a breakdown in how the body processes glucose and regulates insulin sensitivity. NAD⁺ activates sirtuins, which are key regulators of metabolism, helping to improve insulin sensitivity and support healthy weight management efforts.

• Substance Abuse and Addiction Recovery - Recovery from addiction is physically demanding as the brain attempts to heal from chemical dependency and restore natural neurotransmitter balance. NAD⁺ therapy has been shown to significantly reduce withdrawal symptoms and cravings while accelerating the brain's natural healing and detoxification processes.

• Post-Viral Fatigue (Long COVID) - Many patients experience lingering fatigue and brain fog after viral infections due to persistent inflammation and cellular stress. This treatment helps reduce systemic inflammation and restores the cellular energy deficits that often persist long after the initial infection has cleared.

• Fibromyalgia - This chronic pain condition is often associated with oxidative stress and reduced energy production in muscle tissues. By improving mitochondrial efficiency and reducing inflammation, NAD⁺ can help alleviate the widespread pain and tenderness experienced by fibromyalgia patients.

• Age-Related Cognitive Decline - As we age, "brain fog" and memory lapses become more common due to decreased blood flow and cellular repair in the brain. Boosting NAD⁺ levels enhances vascular function and neuronal repair, leading to sharper focus, better memory retention, and improved mental clarity.

Common Symptoms of People Who Benefit from NAD+ Treatments

Individuals who benefit most from this therapy typically report a persistent lack of physical energy that sleep or rest does not seem to resolve. They often describe a sensation of "brain fog," in which focusing on tasks becomes difficult, and memory recall feels slower than before. Many patients experience a general malaise or a feeling that their physical recovery after exercise or illness is significantly prolonged compared to their younger years. It is common for these individuals to experience disrupted sleep patterns or feel unrefreshed even after a full night of sleep.

Mood disturbances, such as increased anxiety or a low-level depression that doesn't respond well to traditional interventions, are also frequent complaints. Physical symptoms may include unexplained muscle weakness, aches without a clear cause, and a weakened immune response, leading to frequent illnesses. Ultimately, these patients feel that their quality of life has diminished and their vibrancy has faded prematurely.

Common Causes of People Who Need This Treatment

The primary driver of this treatment is the natural biological aging process, which inevitably leads to a drastic reduction in NAD⁺ production in the body. However, this decline is often accelerated by chronic stress, which depletes cellular resources as the body fights to maintain homeostasis under pressure. Environmental toxins, such as pollution and heavy metals, cause oxidative stress that rapidly depletes NAD⁺ stores as cells attempt to repair the resulting damage. Poor dietary choices, particularly those high in processed sugars and unhealthy fats, can lead to metabolic inflammation, which further depletes these essential coenzymes.

Excessive alcohol consumption and drug use place a heavy burden on the liver and cellular detoxification pathways, significantly lowering available levels. Sedentary lifestyles and a lack of physical activity contribute to mitochondrial inefficiency, creating a cycle of low energy and depletion. Additionally, chronic inflammation from underlying infections or autoimmune conditions can constantly utilize NAD⁺ for immune responses, leaving little for daily energy.

People navigating the challenges of aging who want to preserve their cognitive function and physical vitality are prime candidates for this protocol. Additionally, individuals in recovery from substance dependency may find it provides the physiological support needed to maintain sobriety and heal the brain. Anyone seeking a holistic, science-backed method to improve their overall wellness and longevity should consider this therapy.

Possible Side Effects

NAD⁺ therapy is generally considered safe and well-tolerated by most patients, but some individuals may experience mild side effects during the infusion process. The most commonly reported sensation is a feeling of warmth or flushing that spreads from the upper body to the head. Some patients describe a sensation of pressure in the chest or head, or a slight tightening in the abdomen or stomach area.

Nausea can occasionally occur, particularly if the infusion rate is set too high for the individual's tolerance level. These symptoms are typically transient and subside almost immediately if the infusion is slowed down or paused for a few moments. Dr. Salerno and his staff closely monitor patients to adjust the drip rate and ensure comfort throughout the procedure. Headaches or lightheadedness are rare but possible, and usually resolve quickly after treatment concludes. It is important to stay hydrated and communicate any discomfort to the medical staff immediately.

Why Patients Choose Dr. John Salerno for this Treatment

Patients choose Dr. Salerno because he refuses to accept the notion that declining health is a normal and acceptable part of getting older. His reputation as a medical detective draws people who are tired of being told their labs are "normal" even though they feel unwell. He offers a level of personalization rare in modern medicine, tailoring NAD⁺ protocols to each individual's specific metabolic needs. His clinic provides a safe, comfortable, and professional environment where patients feel heard, validated, and cared for during their treatments.

Dr. Salerno’s extensive background in functional medicine ensures that this therapy is not used in isolation but as part of a comprehensive health strategy. He integrates this treatment with nutritional guidance and detoxification protocols to maximize the benefits and sustainability of the results. Ultimately, patients trust him because he delivers tangible results that restore their quality of life.

Dr. John Salerno Practices Complementary, Functional, and Integrative Medicine

Dr. John Salerno is a pioneer in functional medicine who believes that true health comes from treating the whole person rather than merely suppressing symptoms. He utilizes a comprehensive approach that blends the best of complementary therapies with rigorous scientific diagnostics to uncover the underlying imbalances affecting your health. His practice focuses on identifying root causes such as nutritional deficiencies, hormonal imbalances, and heavy metal toxicity that traditional medicine often overlooks.

By integrating advanced treatments like NAD⁺ therapy with personalized lifestyle protocols, he helps patients achieve optimal wellness. This integrative philosophy ensures that every treatment plan is tailored specifically to your unique biological needs. Dr. Salerno is dedicated to empowering his patients with the knowledge and tools they need to achieve sustainable, long-term health.

Dr. John Salerno has over 30 Years of Experience

With more than three decades of clinical experience, Dr. John Salerno has established himself as a trusted authority in anti-aging and functional medicine. His extensive career is built on a foundation of continuous learning and a deep commitment to patient care, allowing him to stay at the forefront of medical advancements. Throughout his career, he has successfully treated thousands of patients who had previously struggled to find answers within the conventional medical system.

His vast experience allows him to recognize subtle patterns in patient health that less experienced practitioners might miss. Dr. Salerno’s longevity in the field is a testament to the effectiveness of his protocols and his dedication to patient outcomes. He combines this wealth of clinical wisdom with cutting-edge therapies to deliver results that truly transform lives.

What Can Happen if Low NAD+ Levels Are Left Untreated?

If low NAD⁺ levels are left unaddressed, the body’s cellular repair mechanisms will continue to decline, accelerating the visible and internal signs of aging. You may experience progressive worsening of fatigue that significantly interferes with your work, relationships, and daily activities. Cognitive decline can shift from occasional forgetfulness to more serious issues with memory, focus, and mental processing speed over time. The risk of developing age-related chronic diseases such as diabetes, heart disease, and neurodegenerative disorders increases as mitochondrial function falters.

 Without adequate cellular energy, your body’s ability to recover from injury, illness, or stress becomes severely compromised. Chronic inflammation may go unchecked, leading to persistent pain and a weakened immune system that leaves you vulnerable to infections. Metabolic health often deteriorates, leading to stubborn weight gain and difficulty managing blood sugar levels. Ultimately, ignoring these deficiencies can lead to a significantly reduced quality of life and premature frailty.

Patient Case Studies of the Treatment

Michael, a 52-year-old executive, came to Dr. Salerno complaining of severe burnout, difficulty focusing during meetings, and energy crashes every afternoon. He had tried various caffeine supplements and sleep aids, but nothing seemed to restore his mental clarity or drive. After a comprehensive evaluation, Dr. Salerno initiated a protocol of NAD⁺ IV therapy combined with specific mitochondrial support supplements. By his third session, Michael reported that the "fog" had lifted and he was able to sustain focus for hours without fatigue. He noted that his sleep quality improved dramatically, allowing him to wake up feeling genuinely refreshed for the first time in years. His recovery time after gym sessions shortened, and he felt a renewed sense of motivation in his professional life. Michael continues maintenance therapy monthly and describes the treatment as a "game-changer" for his career and personal life.

Diane, a 45-year-old mother of three, sought help for persistent fatigue and body aches that had persisted for months after a viral infection. She felt trapped in a cycle of exhaustion where even simple household chores felt like climbing a mountain. Dr. Salerno recognized the signs of mitochondrial depletion and recommended NAD⁺ therapy to jump-start her cellular energy production. During her treatment series, Diane began to notice a steady return of her physical strength and a significant reduction in her daily pain levels. She was able to return to her favorite hobby, gardening, and had the energy to keep up with her children again. Diane reported that her anxiety levels, which had spiked during her illness, had smoothed out, leaving her feeling calmer and more resilient. She credits Dr. Salerno’s integrative approach with giving her back her life as an active mother.

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Additional References

• Biology of Aging - National Institute on Aging



• Studying Mitochondrial DNA Sheds Light on the Importance of Vitamins - National Human Genome Research Institute