Glutathione Nature's Antioxidant Powerhouse

Salerno Wellness Glutathione is 99.9% pure and medical-grade, with verified provenance, including certification from a licensed and state-monitored laboratory. It is free from contaminants and additives that could compromise its effectiveness or safety.

-Dr. John Salerno

The Vital Role of Glutathione: A Powerful Antioxidant in Maintaining Health and Combating Disease

One of the biological wonders of life is that numerous chemicals are at play in just about every cell. This not only ensures that a complex biochemical harmony is taking place, but also that a single off-tune component or molecule could disrupt the delicate balance. A wide range of chemicals and enzymes is involved in this process, including antioxidants. The body has a wide-ranging natural defense system that counteracts the harmful effects of oxidation, which can lead to cell death. There are two key components of such an antioxidant system, and one of them is Glutathione.
 
Glutathione is a group of amino acids (protein building blocks) that are produced naturally in the liver, work as antioxidants, and counter the harmful effects of oxidation. Besides countering oxidation, Glutathione also helps build tissues, facilitates their repair, aids in the production of specific proteins and chemicals essential to the body, and plays a crucial role in the immune system. It is an old truth that understanding the intricacies of important body chemicals can go a long way in comprehending various aspects of health and disease.
 
Glutathione is a tripeptide composed of three amino acids: cysteine, glutamine, and glycine. It is the most powerful antioxidant produced by the body and is primarily found in the liver, where its level is the highest. The name glutathione was given to this antioxidant due to its derivation from glutamic acid, cysteine, and glycine.
 
Glutathione works in two phases to reduce the damaging and health-threatening effects of oxidation. 

• In the first step, known as direct free radical scavenging, Glutathione intercepts free radicals, also referred to as reactive oxygen species (ROS), and neutralizes their damaging effects. 

• In the second stage, known as reduction regeneration, Glutathione is converted from its oxidized form (GSSG) to its reduced form (GSH) with the help of an enzyme called glutathione reductase (GR). This is an electron-transfer enzyme that regenerates GSH using reduced nicotinamide adenine dinucleotide phosphate (NADPH). NADPH is a coenzyme that is used in various reactions in the body.

Glutathione is the most abundant antioxidant in the body, and is most required by the cells when glutathione peroxide, hydrogen peroxide, lipid peroxide, and nitric oxide all convert into ROS. Glutathione plays a pivotal role in detoxifying various drugs, toxins, and peroxides.
 
The production of Glutathione involves several steps. The first step consists of the formation of the gamma-glutamylcysteine dipeptide from two substrates: glutamate and cysteine. This dipeptide is then modified by an enzyme called glutathione synthetase, which adds glycine to form the tripeptide glutathione.

Glutathione is now known to have many other functions as well, and is considered to be beneficial for the following reasons:

• As an antioxidant, it defends the body from the oxidative damage that it causes, which is otherwise responsible for causing various chronic diseases like cancer, heart disease, diabetes, etc.

•  It helps in detoxification by binding up with drugs, toxins, heavy metals, and pharmaceuticals, thereby forcing the body to excrete these harmful products.

• The body's immune system needs Glutathione to function at its optimum level.

• Glutathione helps the body in the synthesis and repair of proteins and other chemicals, thereby promoting the growth of new cells and their proper functioning.

• It also helps in the repair of cellular damage that can happen due to many reasons.

• Glutathione has been shown to protect the nervous system against various forms of damage as well, and is being widely researched for the same.

Glutathione treatments have now been tried out in the treatment of various conditions, with some of them being:

• Treatment after chemotherapy: Glutathione has been found to have a positive effect in the repair of nerve damage, caused by anti-cancer drugs like cisplatin, as they have been shown to cause damage to the peripheral nerves, thereby causing a neuropathy that is reduced with the help of glutathione therapy. Cisplatin has also been found to cause some kidney damage and other toxicities that have also been shown to reduce with this therapy.
  
• Lung repair in COVID patients: Recent research has shown that low levels of Glutathione are the cause of the significant lung damage observed in COVID patients, thereby opening the possibility for its therapeutic role in their treatment.
  
• Treatment of Parkinson's and other related diseases: Glutathione has been found to play a role in reducing oxidative stress and inflammation in related neurodegenerative diseases like Parkinson's, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and muscular dystrophy.
  
• Related metabolic disorders: As the disease is also related to oxidative stress, research is being conducted on the use of Glutathione in the treatment of related metabolic disorders like obesity, type 2 diabetes mellitus, and other forms of insulin resistance.
  

Reverse Factor

Aging gracefully begins at the cellular level. Reverse Factor, developed by renowned integrative physician Dr. John Salerno and Christina Rosiello, NP, is expertly formulated to help combat oxidative stress and support your body's natural repair processes.

With targeted ingredients like alpha lipoic acid, quercetin, and trans-resveratrol, Reverse Factor offers advanced antioxidant support to promote cellular health, reduce inflammation, and maintain youthful energy levels.

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IV Administered Treatments

Glutathione can be supplemented; however, due to the structural complexity and nature of the antioxidant, most of the oral forms get denatured, and therefore fail to reach the body at all, or in adequate quantities. The most effective way to increase the body's glutathione levels is through intravenous infusion, which directly enters the bloodstream and initiates the antioxidant process immediately. 



This is the main reason that lower-quality intravenous glutathione injections are now being popularized by IV parlors and Spas offering IV therapy for just about any condition. This has been especially true with the growth of such practices in the spa industry, where many establishments offer glutathione infusions as a "skin lightening" treatment, for energy, or to improve sports performance. 

Patients should always consult a doctor before starting any Glutathione therapy and review the need for such treatment, as well as the appropriate dosages and composition, with them.

Ongoing Scientific Research

Studies are being conducted in various other areas related to Glutathione. These include the multiple roles it plays in aging, neurological health and repair, psychiatric health and diseases, protection of cardiac cells, and many others. The results of these studies have identified alterations in the body's glutathione levels, including the effects of specific stressors, dietary deficiencies, and even genetic polymorphisms. We are coming to a new realization that there could be a large genetic and even a nutritional basis for such variations, with diet playing a pivotal role in deciding the body's capacity to generate Glutathione. Diet and lifestyle factors, such as the consumption of sulfur-rich foods, could play a significant role here.
 
Glutathione is a powerful antioxidant that is naturally found in the liver. With many essential functions, including serving as a tissue builder and repairer, playing a central role in the immune system, and acting as a detoxifier of the body from various drugs and toxins, it is fitting that it has now become the subject of extensive research as we enter the next century. Much more research is yet to be conducted on the various other antioxidants, both to determine their therapeutic potential and to assess any potential adverse health impacts.

Glutathione Treatments at Salerno Wellness

Glutathione Treatments are frequently administered at Salerno Wellness to address the root cause of multiple symptoms that vary in severity. Our treatments are administered intravenously, which is far more efficient than oral supplements and begins working immediately to support your body's healing process. The treatment, managed by Dr. John Salerno, ensures the correct dosage and frequency of therapy.

Only High Quality Glutathione

The value of ongoing medical guidance should not be overlooked, as Spas and IV parlors administer Glutathione based on what a pamphlet might say, rather than experienced and personalized medical care. Key characteristics of high-quality IV glutathione used at Salerno Wellness include:

• Purity: Salerno Wellness Glutathione is 99.9% pure and medical-grade, with verified provenance, including certification from a licensed and state-monitored laboratory. It is free from contaminants and additives that could compromise its effectiveness or safety.

• Sterility: Since it is administered via IV, it must be produced and packaged in a sterile environment to prevent infections.

• Stability: A stable formulation ensures that Glutathione retains its effectiveness during the storage and administration process.

• Proper Dosage: High-quality IV glutathione should be available in appropriate concentrations for therapeutic use, typically decided by healthcare professionals based on individual needs.

• Source: Reputable manufacturers will often provide information about the source of the Glutathione, ensuring it comes from a reliable and ethical source.

Patients often seek IV glutathione for various reasons, including skin brightening effects, anti-aging benefits, and detoxification support. However, it's essential to consult with a healthcare provider before starting any IV treatments to discuss potential benefits and risks.